The Nobel Prize-winning genome editing technology CRISPR/Cas9 was first disclosed in 2012 and changed science forever. Suddenly everyone had the chance to modify the DNA of cells and organisms with an unprecedented precision and flexibility. The precise detection and quantification of such clever experiments however was still reliant on complex, inaccurate or slow and expensive techniques. This was a major obstacle to large scale experiments.
TIDE was developed to provide an inexpensive, fast, and reliable method for assessing the efficiency and precision of gene editing experiments. The analysis algorithm was published in 2014 by scientists Eva K. Brinkman, Tao Chen, Mario Amendola, Bas van Steensel at The Netherlands Cancer Institute (NKI) and gained immediate popularity. With over 2000+ citations, it is one of the most cited papers in the field of DNA biotechnology.
In 2020, Data Curators acquired an exclusive license for the entire TIDE codebase. Data Curators upgraded the code, introduced a command-line interface (CLI) and the option to package the software into a Docker image for safe deployment inside private company networks.
Meet the team
Jelle ten Hoeve
Jelle is a social entrepreneur with a background in computer science, bioinformatics, information security and privacy.
Dr. Lorenzo Bombardelli
Dr. Lorenzo Bombardelli loves being scientist, entrepreneur, and business developer. His professional life is all about exploring the space of opportunities and ideas between business and innovative academic science.